Long-term couple John and Ella Robina are experiencing the struggles of growing older. With John having Alzheimer's and Ella undergoing cancer treatment, they decide to abandon their disease-stricken lifestyles and embark on a journey from Boston to Key West in an attempt to fully live what's left of their lives. Their trusty RV, which they've dubbed "The Leisure Seeker", will be their mode of transportation as they enjoy what may be their last adventure together.

When Frank and Lindsay meet on a way to a destination wedding, they soon discover they have a lot in common: they both hate the bride, the groom, the wedding, themselves, and most especially each other. As the weekend's events continually force them together, and their cheerlessness immediately isolates them from the other guests, Frank and Lindsay find that if they verbally spar with someone long enough, anything can happen.

New York City architect Natalie works hard to get noticed at her job but is more likely to be asked to deliver coffee and bagels than to design the city's next skyscraper. And if things weren't bad enough, Natalie, a lifelong cynic when it comes to love, has an encounter with a mugger that renders her unconscious, waking to discover that her life has suddenly become her worst nightmare, a romantic comedy, and she is the leading lady.

Clara, a young single doctor, has everything she wants, except love. Invited to a family wedding in Mexico, Clara convinces a charming coworker to pose as her current boyfriend, only to run into her old flame at the festivities. Now, with a little help from her colorful family, Clara must choose between two men, and two futures, in this heartwarming romantic comedy.

When aspiring filmmaker David is mandated by a judge to attend a social program at the Jewish Community Center, he is sure of one thing, he doesn't belong there. But when he's assigned to visit the Brooklyn Bridge with the vivacious Sarah, sparks fly and his convictions are tested. Their budding relationship must weather Sarah's romantic past, David's judgmental mother, and their own preconceptions of what love is supposed to look like.

Since she was little, it's been drilled into Amy's head by her dad that monogamy isn't realistic. Now a magazine writer, Amy lives by that credo; enjoying what she feels is an uninhibited life free from stifling, boring romantic commitment, but in actuality, she's kind of in a rut. When she finds herself starting to fall for the subject of the new article she's writing, a charming and successful sports doctor named Aaron Conners; Amy starts to wonder if other grown-ups might be on to something.

Luke and Kate, co-workers at a Chicago brewery, spend their days drinking and flirting. They're perfect for each other, except that they're both in relationships. Luke is in the midst of marriage talks with his girlfriend of six years; Kate is playing it cool with her music producer boyfriend Chris. Beer makes the line between 'friends' and 'more than friends' really blurry.

Celeste and Jesse have been best friends since they can remember. High school sweethearts, they eventually got married--and now they're getting divorced. While their friends don't think the couple can stay friends after the divorce, Celeste and Jesse are determined to prove them wrong. But when Jesse begins dating again, Celeste finds it harder to move on than she thought it would be.

Her legs are waxed, her lips are glossed, her gun is ready. FBI agent Gracie Hart is going undercover as one of the hopefuls to be the next Miss United States. But Gracie, whose idea of a fashion accessory is the set of handcuffs she slaps onto lawbreakers, doesn't have a beauty pageant bone in her body.